Effect of candesartan and amlodipine on primary hypertension with early renal damage

Aim To investigate the efficacy of candesartan and amlodipine on primary hypertension with early renal damage.Methods 83 microalbuminuria positive outpatients with essential hypertension(1,2)were divided into amlodipine group(5 mg·d-1)with 42 cases and candesartan group(8 mg·d-1)with 41 cases according to the order of visits,with a course of 3 months.The difference was observed in blood pressure,Scr,UMALB,Uα1-MG and CystC before and after treatment.Results Blood pressure of the two groups descended more significantly than those before treatment(P0.01),but comparing the blood pressure between the two groups after treatment,the difference is not significant(P0.05);Scr of the two groups had no changes before and after treatment(P0.05);UMALB and CystC of the two groups are lower than those before treatment(P0.05),and the candesartan group was better than amlodipine group(P0.05).So are Uα1-MG of the two groups,with a significant drop(P0.01).Conclusion Both candesartan and amlodipine have a good antihypertensive effect to reduce levels of UMALB,Uα1-MG and CystC,but the effect of candesartan is better than that of amlodipine on primary hypertension with early renal damage.