Clinicopathological Analysis of Dermatofibrosarcoma Protuberans

Objective: To investigate the clinicopathological characteristics, differentiation and differential diagnosis of dermatofibrosarcoma protuberans (DFSP). Methods: HE and immunohistochemistry were used to analyze 24 cases with DFSP. Results: The storiform was observated in all DFSP and other spindal cell tumors. But it was not specialized in DFSP. The tumor comprised a variably proportional mixture of fibrous and myxoid areas or pigmented or fibrosarcomatous change. Positive rates of immunostainings were: 100% in Vimentin , 29.1% in AACT, 91.7% in CD34 and 75% in VEGF respectively in cases. Conclusions: DFSP originates from the primary mesenchyme cell of derma and differentiated into various mesenchyme tissues. So the tumor may be classifed subclassfication on histologic features. The diagnosis and prognosis of the subclassification of DFSP are different. The HE staining may diagnose the tumor. Immunohistochemistry staining of CD34 and VEGF may play an important role in the differential diagnosis.