2006•Chongqing Yike Daxue xuebaoRequires access

Investigation of verapamil reverse the drug resistance of KBV200 cell line

Hongyan Chen

Abstract

Objective: To make a study of KBV200 cell line on its multidrug resistance and provide experimental data for clinical individual chemotherapy.Methods:MTT reduction assay was used to investgate the inhibition of 8 common chemotherapetic agents on KBV200 cell line.Result:Vincristine、Adriamycin、Bleomycin、Cyclophosphamide and Arabinosyl Cytosine have poorer inhibition than Harrihgtonine、Cicplatin and 5-Fu on KBV200 cell line.Conclusion:KBV200 cell line is multidrug resistance to Vincristine、Adriamycin、Bleomycin、Cyclophosphamide and Arabinosyl Cytosine.

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Available abstract

Key concepts: Multiple drug resistance, Vincristine, Bleomycin, Verapamil, Cell culture, Drug resistance, Pharmacology, Cyclophosphamide