2006•Chongqing yixueRequires access

Investigation of the effect of combined matrine and chemotherapeutic agents on P-gp of KBV200 cell line

Yan Shu

Abstract

Objective To observe the effect of matrine in combination with 6 chemotherapeutic agents vincristine,adriamycin,bleomycin,cyclophospharmide,5-Fu,cisplatin on the expression of P-glycoprotein(P-gp) of KBV200 cell line.Methods Flowcytometer(FCM) assay was used to investigate the expression of P-gp and the effect on expression of KBV200 cell.Results Matrine in combination with vincristine(VCR) and adriamycin can reverse the multidrug resistance(MDR) by decreasing the expression of P-gp.Conclusion Matrine in combination with vincristine and adriamycin can cut down the expression of P-gp of the KBV200 cell line.

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Key concepts: Matrine, Vincristine, Multiple drug resistance, Bleomycin, P-glycoprotein, Cisplatin, Pharmacology, Cell culture