2011•Hainan yixueRequires access
Ulinastatin combined with hemoperfusion in the treatment of severe organophosphorus pesticide poisoning
Yang Hui-wen
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Abstract
Objective To study clinical efficacy of ulinastatin combined with hemoperfusion in the treatment of severe organophosphorus pesticide poisoning.Methods 30 patients with severe organophosphorus pesticide poisoning were randomly divided into experimental group(UTI+hemoperfusion,n=15) and control group(conventional therapy+hemoperfusion,n=15).The control group were given comprehensive treatment of routine gastric lavage,catharsis,atropine,respiratory support,and hemoperfusion.The experimental group based on the above given ulinastatin 200 000 u intravenous,twice daily.Observed two groups of patients with total amount of atropine treatment,recovery time of cholinesterase activity,two groups of patients before and after treatment 1 h,2 h,24 h,48 h levels of TNF-α,IL-6,hs-CRP.Results Levels of TNF-α,IL-6,hs-CRP of patients in two groups were significantly decreased compared with them before treatment(P0.05);after treatment each time point in the experimental group TNF-α,IL-6,hs-cRP were lower than those in the control group(P0.05);the experimental group total amount of atropine treatment and cholinesterase activity recovery time were significantly lower than those in the control group(P0.05).Conclusion Ulinastatin combined with hemoperfusion can reduce the systemic inflammatory response syndrome,which significantly increase efficacy in the treatment of severe organophosphorus pesticide poisoning.