2010•Lishizhen Medicine and Materia Medica ResearchRequires access
Protective Effects of Supplementing "Qi"-Nourishing "Yin" and Disperse Blood Stasis-Dredge Collateral Herbs on Kidney of Diabetic Rats
Shang Ya-ru
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Abstract
Objective To investigate the effects of supplementing qi-nourishing yin and disperse blood stasis-dredge collateral herbs on oxidative stress in the kidney of diabetic rats and its mechamisms.Methods SD rats were randomly divided into 6 groups:Nephrectomy group,model group,irbesatan group,TCM low dose group,TCM middle dose group,and TCM high dose group,and were adminstered with the medicine respectively.In the sixth week,24 h urine protein(U Pro),renal function,the content of MDA,and the activity of SOD were detected.Results In irbesatan,TCM low dose and middle dose groups,the levels of UPro and MDA were significantly decreased(P0.05),and the activity of SOD was significantly enhanced as compared to model group(P0.05).In all treated groups renal function was also improved(P0.05).Conclusion Supplementing qi-nourishing yin and disperse blood stasis-dredge collateral herbs can protect the kidney of diabetic rats effectively by anti-oxidative stress.