Insulin resistance in patients with obesity accompanying hypertriacylglycemia

Objective To investigate insulin resistance level in patients with obesity accompanying hypertriacylglycemia.Methods Ninety out-patients received health examination in 2004 with BMI(body mass index) over 25kg/m~2 were enrolled.Blood pressure,height,weight,waistline,hip circumference,body lipid proportion,body lipid mass,blood lipid,blood uric acid,glycosylated hemoglobin(HbAlc),blood glucose and insulin level at fasting and 2 hours after taking 75g glucose were measured and homeostasis model assessment(HOMA) were chosen to evaluate insulin resistance level(HOMA-IR).Results ①The prevalence of hypertriacylglycemia,hypercholesterolemia and ortholiposis in this obese group were 36.7%,37.8% and 25.6%,respectively.②Levels of HOMA-IR and WHR were higher in patients with hypertriacylglycemia than in normal triglyceride ones((P=)0.008,P=0.012).③Blood uric acid,body lipid mass,FBS and FINS were higher in insulin resistance group than those without insulin resistance(P=0.043,P=0.005,P=(0.01),P=0.000).④HOMA-IR index was positively correlated with body lipid mass and TG level,respectively(r=0.306,P=0.000,n=65;(r=)0.288,P=0.000,n=81).Conclusion Insulin resistance exist in these obese accompanying hypertriacylglycemia subjects,and screening for these disorders is necessary in obese patients.