Insulin resistance in obese accompanying hypercholesterolemia patients

Objective To investigate insulin resistance level in obese accompanying hypercholesterolemia patients.Methods Ninety six out-patient clinic subjects receiving health examination in 2007 with BMI (body mass index) over 28 kg/m2 were enrolled.Blood pressure, height, weight, waistline, hip circumference, body lipid proportion, body lipid mass, blood lipid, blood uric acid, glycosylated hemoglobin (HbA1c), blood glucose and insulin level at fasting and 2 hours after taking 75 g glucose were measured and homeostasis model assessment (HOMA) were chosen to evaluate insulin resistance level (HOMA-IR).Results ① The prevalence of hypercholesterolemia, hypertriacylglycemia, combined hyperlipidemia and ortholiposis in this obese group were 37.5%, 7.3%, 31.2% and 24%, respectively.②Levels of WHR and HOMA-IR were higher in patients with hypercholesterolemia than in normal cholesterol ones (0.92 vs 0.89, P=0.037; 4.42 vs 3.56, P=0.032); ③Weight, waistline, hip circumference, waist/hip ratio, BMI, body lipid proportion, body lipid mass, cholesterol, FBS and blood uric acid were higher in insulin resistance group than those without insulin resistance (73.04 vs 67.78, P=0.026; 94.49 vs 87.83, P=0.001; 105.14 vs 100.97, P=0.009; 0.90 vs 0.87, P=0.049;29.74 vs 27.44, P=0.002;34.63 vs 32.25, P=0.049;25.11 vs 21.24, P=0.003;5.74 vs 5.44, P=0.041;5.40 vs 4.45, P=0.006; 440.52 vs 355.86, P=0.017).④HOMA-IR index was positively correlated with body lipid mass, cholesterol, triglyceride level, WHR and BMI, respectively (r=0.260,P=0.03,N=70;r=0.636,P=0.023,N=87;r=0.228,P=0.033,N=87;r=0.306,P=0.04,N= 87;r=0.344,P=0.001,N=87).Conclusion ② Insulin resistance exist in these obese accompanying hypercholesterolemia subjects and screening for these disorders is necessary in obese patients.