The expression of CD34 and vascular endothelial growth factor in gastric carcinoma and its clinical application

Objective To discuss the relationship between the expression of CD34,VEGF in the gastric carcinoma tissue and the biological behavior.Methods The expression of CD34,VEGF from 55 cases of gastric cancer tissue and gastric mucosa tissue adjacent to carcinoma were determined by the immunohistochemistry.And we analyzed the relationship between MVD count,the expression of CD34,VEGF and the biological behavior of gastric cancer and evaluated the role of VEGF in the tumor angiogenesis.Results VEGF and MVD count expressed in gastric cancer tissue were significantly higher than those in the normal gastric mucosa tissue adjacent to carcinoma.(P0.05) And the expression of VEGF in the gastric cancer tissue had a positive relation to the MVD count(r=0.728).There was a significant difference for VEGF expression of gastric cancer tissue and MVD count among different invasive depths groups in the gastric wall,lymph node metastasis groups,none lymph node metastasis groups,recent distant metastasis and none distant metastasis,that is,with the higher invasive depths groups in the gastric wall,the appearance of lymph node and recent distant metastasis,the VEGF expression were enhanced and MVD count increased,but there were not significant differences in different tissues of different differentiation degrees for the VEGF expression and MVD count.Conclusion Tumor angiogenesis existed in the gastric cancer tissue,where the VEGF played an important role and the biological behaviors of gastric cancer could be well reflected by MVD count and the expression of VEGF.