Study on application of insulin pump therapy in treatment of newly diagnosed 20 cases of type 2 diabetes

Objective To observe the efficacy of short-term intensive insulin therapy in treatment of newly diagnosed patients with type 2 diabetes and its effects on function of β cells of pancreatic islet.Methods The efficacy of 20 patients with newly diagnosed type 2 diabetes under a period of 10~18 days of insulin pump therapy was studied.Levels of fasting plasma glucose(FPG) and 2 h postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c),blood lipids and insulin secretion at first phase and C peptide area under the curve(AUC) were determined and their results before treatment were compared with those after treatment.Results Blood levels of fasting,postprandial glucose,glycosylated hemoglobin and lipids were significantly decreased in newly diagnosed patients with type 2 diabetes after intensive insulin therapy in comparison with those before the treatment(P0.01).After follow-up for 6 months,the first phase secretion of insulin and β cell function of islet were restored in varying degrees in majority of patients.Conclusion The application of insulin pump therapy and rapid control of blood level of glucose in newly diagnosed patients with type 2 diabetes can significantly increase the insulin secretion and the sensitivity to insulin in peripheral tissues.