Drug-resistance of Staphylococcus Isolated from the Hospital

OBJECTIVE To investigate the drug-resistance of Staphylococcus species isolated from clinic in our hospital from 2000 to 2003, so as to provide the reference for choosing antibiotics of empirical therapy of bacterial infection. METHODS Using K-B antibacterial disk susceptibility test, the drug-resistance of 977 Staphylococcus aureus (SAU) strains and 607 coagulase negative Staphylococcus (CNS) strains from patients was measured. Meticillin-resistant SAU and CNS from them were detected by using the method of salt agar screen. RESULTS Among 977 SAU strains (14.4%) and 607 CNS strains (8.9%) of 6 602 strains of first 9 pathogens isolated from patients from 2000 to 2003 in our hospital, 821 MRSA strains and 524 MRCNS strains were detected (84% and 86.3%). The drug-resistant rate of MRS to ciprofloxacin, erythromycin, clindamycin and compound sulfamethoxazole was all over 40%. The drug-resistant rate of MRSA to cefazolin was high (90%), and the drug- resistant rate of MRCNS to cefazolin was low (40%). There was no drug-resistant Staphylococcus strain to vancomycin being found. CONCLUSIONS Gram negative bacilli ware also the most commom pathogens isolated from clinic in our hospital, and there is a high proportion of MRSA and MRCNS. MRS production has increased in last 4 years. Measures should be taken to control the spread of MRS strain.