OprD Expression and Imipenem Resistance in Pseudomonas aeruginosa

Pseudomonas aeruginosa is an opportunistic pathogen that produces highly resistant to antibiotic treatment.Here we show a presence of correlation between oprD expression and imipenem resistance.Minimal inhibitory concentration (MIC) for planktonic cells of P. aeruginosa was measured using E test.The results revealed the presence of oprD expression in 10 strains of P. aeruginosa isolates from patients with cystic fibrosis in order to evaluate their impact on imipenem susceptibility profiles.We investigated the relation between oprD gene expression and imipenem susceptibility profile showed isolates.Surprisingly, the imipenem-susceptible (P8) has low oprD expression that appeared in imipenem-susceptible, indicated a correlation of other mechanisms.This work forms a basis for future studies revealing the mechanisms of imipenem resistance in P. aeruginosa.