1990•KanzoOpen access

Effect of OK-432 on production of interleukin 1 and tumor necrosis factor by mouse Kupffer cells.

Norifumi Kawada, Itaru HASEGAWA, Yuzo ICHIKAWA, Toukan SHIN, Hiroko TSUTSUI, Yasuhiro MIZOGUCHI, Kenzo KOBAYASHI, Yoshiko NAKAMOTO, Takeyuki Monna, Seiji Morisawa, Sukeo Yamamoto

Open full text 0 citations

Abstract

Kupffer細胞のinterleukin 1 (IL-1)およびtumor necrosis factor (TNF)産生に及ぼすOK-432の影響について検討した.OK-432は単独でもKupffer細胞のIL-1産生を増強させ,またlipopolysaccharide (LPS)存在下では,IL-1, TNF産生を共に増強させた.また,OK-432を静注したマウスでは,肝の粘着性細胞が増加し,LPS誘導IL-1, TNF産生能も正常のKupffer細胞に比較して上昇した.以上の結果から,OK-432はin vitroならびにin vivoにおいて肝のKupffer細胞や粘着性細胞のIL-1ならびにTNF産生を増強することが明らかとなった.このことは,OK-432が肝局所細胞を活性化させ,免疫増強的に作用することを示唆するものと考えられる.

Open-access reader

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Tumor necrosis factor alpha, Tumor necrosis factor α, Kupffer cell, Lipopolysaccharide, Interleukin, In vivo, Interleukin 6, Cytokine