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Requirement for the continual presence of lipopolysaccharide for production of tumor necrosis factor by thioglycollate‐induced peritoneal murine macrophages

George E. Gifford, Marie‐Luise Lohmann‐Matthes

Open publisher page 52 citations

Abstract

This work demonstrates the need for the continued presence of lipopolysaccharide (LPS) for tumor necrosis factor (TNF) production by thioglycollate-induced peritoneal macrophages. Removal of LPS at any time resulted in the abrupt cessation of further TNF production. The readdition of LPS resulted in further production of TNF but the yield was limited to the amount that would have been produced had the LPS not been removed.

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What this paper is about

This work demonstrates the need for the continued presence of lipopolysaccharide (LPS) for tumor necrosis factor (TNF) production by thioglycollate-induced peritoneal macrophages. Removal of LPS at any time resulted in the abrupt cessation of further TNF production. The readdition of LPS resulted in further production of TNF but the yield was limited to the amount that would have been produced had the LPS not been removed.

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OpenAlex reports 52 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

This work demonstrates the need for the continued presence of lipopolysaccharide (LPS) for tumor necrosis factor (TNF) production by thioglycollate-induced peritoneal macrophages. Removal of LPS at any time resulted in the abrupt cessation of further TNF production. The readdition of LPS resulted in further production of TNF but the yield was limited to the amount that would have been produced had the LPS not been removed.

Key concepts: Lipopolysaccharide, Tumor necrosis factor alpha, Tumor necrosis factor α, Macrophage, Necrosis, Peritoneum, Immunology, Tumor necrosis factors

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Requirement for the continual presence of lipopolysaccharide for production of tumor necrosis factor by thioglycollate‐induced peritoneal murine macrophages — Research Paper | ScholarLens