GW24-e0017 The clinical research of Bushen Huoxue therapy on depression of patients with parkinson’s disease

Objectives To study the effects of Bushenhuoxue Therapy on depression of patients with Parkinson’s disease. Methods Totally 96 patients were enrolled and randomised into two groups with 46 patients in the treatment group and 50 patients in the control group. Both groups were taking western medicine as basic treatment. The treatment group was treated with Bushen Huoxue Herbs additionally. The observation was carried out for 9 months. Using Encephalofluctuograph Technology (ET) and Hamilton Depression Scale (HAMD) to measure the changes of cerebral neurotransmitters and scale scores in both groups at baseline time, 3, 6 and 9 months later to evaluate the effects of Bushen Huoxue Herbs. Results In the treatment group, 5-hydroxytryptamine (5-HT), noradrenaline (NE)and Dopamine (DA)levels increased with statistical difference (P < 0.05), especially of 5-HT and DA levels (P < 0.01); compared to the control group, 5-HT and DA levels were increased significantly (P < 0.05). After treatment, the scores of the HAMD scale was significantly decreased (P < 0.05). No adverse effects were found in this trial. Conclusions Bushen Huoxue Therapy can improve depression of PD patients by increasing the levels of 5-HT, NE and DA in the brain and decreasing the scores of the HAMD scale with reliable effects.