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1992•Japanese Journal of Oral & Maxillofacial SurgeryOpen access

Issues on immunohistochemical staining of proliferating cell nuclear antigen(PCNA).

Tatsuo Tsuji, Kohsuke Sasaki, Yuka Kimura, Kanji Maeda, Akihiro Kanekawa, Takashi Inoue, Yoshikazu Hayatsu, Fumihiko Shinozaki

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Abstract

PCNA score was measured in oral lesions including malignant tumors in a total of 108 cases, and the relationship of it to other cell proliferation markers, Ki-67, S phase fraction, AgNORs was also investigated. Average PCNA scores of 22.8% closely related to Ki-67 scores of 24.1% suggesting that PCNA positive cells represented not only S phase cells but also other cycling phases. The fact that PCNA scores was significantly different between malignant and nonmalignant lesions, suggested the difference in growth activity.

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What this paper is about

PCNA score was measured in oral lesions including malignant tumors in a total of 108 cases, and the relationship of it to other cell proliferation markers, Ki-67, S phase fraction, AgNORs was also investigated. Average PCNA scores of 22.8% closely related to Ki-67 scores of 24.1% suggesting that PCNA positive cells represented not only S phase cells but also other cycling phases. The fact that PCNA scores was significantly different between malignant and nonmalignant lesions, suggested the difference in growth activity.

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Available abstract

PCNA score was measured in oral lesions including malignant tumors in a total of 108 cases, and the relationship of it to other cell proliferation markers, Ki-67, S phase fraction, AgNORs was also investigated. Average PCNA scores of 22.8% closely related to Ki-67 scores of 24.1% suggesting that PCNA positive cells represented not only S phase cells but also other cycling phases. The fact that PCNA scores was significantly different between malignant and nonmalignant lesions, suggested the difference in growth activity.

Key concepts: Proliferating cell nuclear antigen, Immunohistochemistry, Pathology, Medicine, Staining, Cell, Cell growth, Antigen

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