Expression of Proliferating Cell Nuclear Antigen(PCNA) in Laryngeal Squamous Cell Carcinomas

Proliferating cell nuclear antigen(PCNA) indicates the cellular kinetic activity during the late G1 and S phase. Among the various approaches for evaluating the proliferative activity, PCNA has been recently introduced as an antigenic marker of cellular proliferation. The purpose of this study was to analyze the relationship between PCNA expression and clinicopathological findings in laryngeal squamous cell carcinomas. Fourty-one cases of laryngeal squamous cell carcinomas were analyzed for the detection of PCNA by immunohistochemical technique. The PCNA expression rates were 34.34 ±18.02%, 55.23±12.97%, and 78.53±5.74% in well differentiatied, moderately differentiatied and poor differentiatioed squamous cell carcinomas of larynx respectively with statistical significance(p < 0.05). There was no correlation between PCNA expression and clinical findings. In conclusion the PCNA index was related to cellular differentiation regardless of T stage, nodal involvement, recurrence and treatment results.