1996•The Journal of Toxicological SciencesOpen access

DERMATOTOXICITY STUDIES OF CALCIPOTRIOL (MC903) OINTMENT : Primary Skin Irritation, Skin Sensitization, Phototoxicity and Skin Photosensitization

Toshiro SUZUKI, Toshihiro Kato, Tadahatu KITAGAKI, Masahiro Ono, Kiyomi SHIRAKAWA, M. Nagata, Ryoji Konishi

Abstract

MC903 ointment was studied on primary skin irritation in rabbits and skin sensitization, skin photosensitization and phototoxicity in guinea-pigs. 1. MC903 ointment, ointment base and deteriorated MC903 ointment induced erythematous changes in rabbit skin. These erythematous changes were not so serious, and they were classified as a mild irritant. 2. MC903 ointment was almost negative in skin sensitization study. 3. MC903 ointment has no skin phototoxicity in guinea-pigs. 4. MC903 ointment has no skin photosensitizing activity in guinea-pigs.

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Key concepts: Phototoxicity, Skin irritation, Irritation, Sensitization, Dermatology, Medicine, Skin sensitization, Chemistry