2010•Zhongguo weishengtaixue zazhiRequires access
Study on structure of integron in multi-drug resistant E. coli.
Bin Li, Fu Qiang, Huang XinHong, Yingping Cao, Pan Yuhong
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Abstract
Objective To study the relationship between integrons and multi-drug resistance in E.coli.Method Class I and Ⅱ integrons were detected by PCR;Various regions of Class I integron were sequenced.Result Class I integrons were screened from 93 isolates with the positive rate of 60.2%.Three types of integrons were detected with their lengths being 1000 bp,1600 bp and 2000 bp respectively.Most of these genes carried aadA and dfrA gene cassatte.Class Ⅱ integrons were not detected.Conclusion Integrons are important molecular mechanism in the development of multidrug resistance of E.coli.