2010•Xiandai shengwu yixue jinzhanRequires access
Pharmacokinetics of atorvastatin in plasma of New Zealand rabbits by high efficiency liquid chromatography.
Dou Yu-hong, WU Xiong-jun, Jiang Yan
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Abstract
Objective:To study pharmacokinetics of atorvastatin tablets in plasma of New Zealand rabbit by High efficiency liquid chromatography(HPLC) method.Methods:Eighteen rabbits were divided three groups:Control group,10 mg/kg·d group and 15 mg/kg·d group.A single dose atorvastatin tablets was given to 12 rabbits.The pharmacokinetics were measured.Results:The main pharmacokinetic of 10 mg/kg·d group and 15 mg/kg·d group test tablets were as follow:AUC0～t/μg·L-1·h were(619.58±215.45)and(1138.34±422.32),AUC0～∞ /μg·L-1·h were(655.68± 242.83) and(1216.57±353.64),Cmax/μg·L-1 were(455.81±168.52) and(896.53±168.5.8),MRT0～t /h were(3.68±0.75) and(5.73±0.56),MRT0～∞ /h were(3.83±0.91) and(5.25±0.48),Tmax /h were(2.51±0.82) and(3.68±0.33),T1/2 /h were(4.22±0.55) and(9.51±0.67).Conclusion:The method is simple and reproducible,and is suitable for content determination and pharmacokinetic of atorvastatin.