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2010•Asian Journal of Research in ChemistryRequires access

Ultra-Violet Spectrophotometric Method for Estimation of Azelnidipine from Bulk Drug and Pharmaceutical Formulation

Rajan V. Rele, Sandip P. Patil

Open publisher page 4 citations

Abstract

A simple, rapid sensitive and precise UV spectrophotometric method has been developed for the estimation of azelnidipine from bulk drug and pharmaceutical formulation. In this method azelnidipine showed maximum absorbance at about 254 nm in methanol. Beer’s law was followed in the concentration range of 1 to 20 μg/ml. Regression equation was found to be y = 0.0478 x + 0.0013 and coefficient of correlation was 0.9999. The proposed method is sensitive, accurate, reproducible and useful for the estimation of azelnidipine from bulk drug and pharmaceutical formulation.

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What this paper is about

A simple, rapid sensitive and precise UV spectrophotometric method has been developed for the estimation of azelnidipine from bulk drug and pharmaceutical formulation. In this method azelnidipine showed maximum absorbance at about 254 nm in methanol. Beer’s law was followed in the concentration range of 1 to 20 μg/ml. Regression equation was found to be y = 0.0478 x + 0.0013 and coefficient of correlation was 0.9999. The proposed method is sensitive, accurate, reproducible and useful for the estimation of azelnidipine from bulk drug and pharmaceutical formulation.

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Available abstract

A simple, rapid sensitive and precise UV spectrophotometric method has been developed for the estimation of azelnidipine from bulk drug and pharmaceutical formulation. In this method azelnidipine showed maximum absorbance at about 254 nm in methanol. Beer’s law was followed in the concentration range of 1 to 20 μg/ml. Regression equation was found to be y = 0.0478 x + 0.0013 and coefficient of correlation was 0.9999. The proposed method is sensitive, accurate, reproducible and useful for the estimation of azelnidipine from bulk drug and pharmaceutical formulation.

Key concepts: Beer–Lambert law, Pharmaceutical formulation, Absorbance, Drug, Chemistry, Methanol, Correlation coefficient, Dosage form

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