2012•Asian Journal of Pharmaceutical AnalysisRequires access

A New Analytical Method Development and Validation for Estimation of Ciprofloxacin in Bulk and Pharmaceutical Dosage Form

Manoranjan Sabat, Sharada Nalla, Goli Venkateswarlu, Sravan Prasad Macherla, Praveena Kumari Matta, S. Madhu Chandaka

Abstract

A sensitive, precise, accurate and simple UV spectrophotometric method has been developed for estimation of ciprofloxacin in bulk and pharmaceutical dosage form. The drug shows maximum absorbance at 273 nm (λmax). The linearity was observed in the concentration range of 5-50mcg/ml. The proposed method has been applied successfully to the analysis of cited drug in pharmaceutical formulation. Recovery study was performed to confirm the accuracy of the method. The method was validated as per ICH guide lines.

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Key concepts: Dosage form, Absorbance, Ciprofloxacin, Pharmaceutical formulation, Biomedical engineering, Linearity, Chromatography, Materials science