Distribution and drug resistance of pathogens causing biliary tract infection.

OBJECTIVE To understand the pathogenic distribution of biliary tract infections and antibiotic resistance and provide bases for rational application of antibiotics in clinics.METHODS The biliary infection bile specimens were collected for aerobic bacteria culture,then the identification and susceptibility test was performed and the statistical analysis was carried out to the results.RESULTS A total of 364 strains were isolated,from which Gram-negative bacilli were 242 strains,accounted for 66.5%,mainly were Escherichia coli(26.1%),Klebsiella pneumoniae(8.3%),Enterobacter cloacae(7.4%),and Pseudomonas aeruginosa(6.9%);while Gram-positive bacteria were 120 strains,accounted for 33.0%,mainly were Enterococcus(13.0%),E.faecium(9.6%) and Staphylococcus(6.6%);drug susceptibility results showed that the drug resistant rates of Gram-negative bacilli to imipenem,meropenem,piperacillin/tazobactam,cefoperazone/sulbactam and cefepime were relatively low(0.0-29.5%),but to quinolones and aztreonam were high(33.3-88.9%);Gram-positive cocci were 100.0% sensitive to vancomycin and teicoplanin,but their drug resistant rates to quinolones and macrolide were high(38.3-85.7%).CONCLUSION Biliary tract infection is primarily caused by Gram-negative bacilli.Because of the wide distribution of pathogens and serious drug resistance,the monitoring of bacterial resistance should be enhanced to improve the cure rate.