Clinical efficacy of modified Dihuang decoction on the treatment of primary nephritic syndrome and its effect on cytokines.

Objective To observe the clinical efficacy of modified Dihuang decoction combined with conventional western medicine for the treatment of primary nephritic syndrome. Methods One hundred and eight cases of primary nephrotic syndrome were randomly divided into treatment group (54 cases) and control group (54 cases). Treatment group was given modified Dihuang decoction combined with conventional western medicine, the control group was treated with conventional western medicine only. IL-6, IL-8 and TNF-α content in blood of the two groups were observed before treatment and one month after treatment. Results The therapeutic effect of the treatment group was better than the control group (P 0.05). IL-6, IL-8 and TNF-α content in blood of both groups decreased after treatment. There was significant statistical difference between the treatment group and the control group. Conclusion Combination of traditional Chinese and western medicine is better than western medicine in lowering the content of IL-6, IL-8 and TNF-α in blood. The study provides a basis at the molecular level for the combination treatment on primary nephritic syndrome.