2013•Asian Journal of Research in ChemistryRequires access

Spectrophotometric Estimation of Ofloxacin in Pharmaceutical Dosage Form

K. Navyatha, P. Jyothi Kanaka Durga, B. Madhuri, K. Madhavi, N Delhiraj

Abstract

Simple, accurate and rapid Spectrophotometric method was developed for the estimation of ofloxacin in tablet dosage form. The method is based on the absorption of electromagnetic radiation by cefixime at the maximum wavelength at 294 nm in 0.1M Hydrochloric acid as solvent. Beer's law was obeyed in the concentration range of 10–80 μg/ml. The percentage assay for commercial formulation was found to be 100.02±0.82.Recovery value was found to be 99.95±0.54.

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Key concepts: Ofloxacin, Cefixime, Hydrochloric acid, Dosage form, Chromatography, Absorption (acoustics), Chemistry, Materials science