2011•Asian Journal of Pharmaceutical AnalysisRequires access

Simultaneous Estimation of Cefixime and Ofloxacin in Bulk and Tablet Dosage Form

Saravanan Rajendran, Nayantara Santhi, P. Kumar Nallasivan, Wesley Solomon, Ramanujam Narayanan

Abstract

Two simple, rapid, accurate and price spectrophotometric methods have been developed for simultaneous eatimation of cefixime and ofloxacin in bulk and in tablet dosage form. Method A involves simultaneous equations at 290.4 nm (λmax of Cefixime) and 297.4nm (λmax of Ofloxacin). Method B involves Absorbance ratio method at 282.0 nm (iso-absorptive point) and 297.4 nm (λmax of Ofloxacin) using ethanol as a solvent. The linearity was observed in the concentration range of 5–25 μg/ml for Cefixime and 2–10 μg/ml for Ofloxacin. The results of analysis have been validated statically and by recover studies and were found satisfactory.

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Key concepts: Cefixime, Ofloxacin, Absorbance, Dosage form, Chromatography, Mathematics, Materials science, Biomedical engineering