2003•中国临床康复Requires access
The relativity of the activity change of tissue—type plasminogen activator and type 1 plasminogen activator inhibitor in patients with cerebral infarction and defect of nerve function
杜小平, 张乐
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Abstract
AIM：To explore the dynamic changes of the activity of tissue-type plasminogen activator(t-PA) and type 1 plasminogen activator inhibitor (PAI-1) and its clinical significance by observing the activity of t-PA and PAI-1 in patients in acute and recovery phases of arteriosclerotic cerebral infarction.METHODS:Testing the activity of plasme t-PA and PAI-1 of 91 patients with arteriosclerotic cerebral infarction and 80 healthy old ages by Chromgenic substrate methods and controlling them.RESULTS:The activity of t-PA in acute and recovery stage of arteriosclerotic cerebral infarction patients were apparently lower than that of control and the activity of PAI-1 were higher than that of control.volume of cerebral infarction was negatively related to the activity of t-PA and positively related to the activity of PAI-1.CONCLUSION:The plasma fibrinolytic activities of the acute and recovery stage patients with arteriosclerotic cerebral infarction declined.