Effect of Substituents on the Antifungal Activity of 4-ThiazoIidinones derived from 4-Methoxybenzalanilines
M.R. Manrao, Monika Jolly, Jyoti Sharma, P.S. Kalsi
Abstract
M.R. Manrao, Monika Jolly, Jyoti Sharma, P.S. Kalsi
Abstract
4-Thiazolidinones with unsubstituted N-phenyl ring and having hydroxy or thio group in ortho position of the N-phenyl ring have been synthesized by condensing thioglycolic acid and 2-mercaptopropionic acid with 4-methoxybenzalaniline, 4-methoxybenzal-2-thioaniline and 4-methoxybenzal-2-hydroxyaniline. These have been characterized on the basis of elemental analysis and spectral studies. Those having hydroxy group in the N-phenyl nucleus have been found to be effective fungicides, particularly against Alternaria alternata and Helminthosporium maydis by the spore germination inhibition technique.
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4-Thiazolidinones with unsubstituted N-phenyl ring and having hydroxy or thio group in ortho position of the N-phenyl ring have been synthesized by condensing thioglycolic acid and 2-mercaptopropionic acid with 4-methoxybenzalaniline, 4-methoxybenzal-2-thioaniline and 4-methoxybenzal-2-hydroxyaniline. These have been characterized on the basis of elemental analysis and spectral studies. Those having hydroxy group in the N-phenyl nucleus have been found to be effective fungicides, particularly against Alternaria alternata and Helminthosporium maydis by the spore germination inhibition technique.
Key concepts: Thioglycolic acid, Antifungal, Alternaria alternata, Ring (chemistry), Spore germination, Thio-, Germination, Chemistry