Epidemiology of oral yeast colonization and drug resistance of the involved fungi.

Objective:To investigate the epidemiology of oral yeast colonization and drug resistance amongst clinical patients.Methods:Oral examination and microbial swabs were obtained from a total of 92 inpatients for yeast culture in order to reveal the prevalence of Candida pelliculosa colonization by isolation and cultivation of fungi,and to detect its susceptibility to fluconazol,amphotericin B,ketoconazole,fluorocytosine,itraconazole.Results:Candida pelliculosa colonization was found in 57.61%(53/92) of these patients,most of whom were suffering from cardiovascular and cerebrovascular diseases followed by respiratory tract infection.The prevalence of Candida pelliculosa colonization was significant higher among those over 60 years old compared with their younger counterparts(P0.05).It was also revealed there were 28 Candida albicans,8 Candida tropicalis and 17 other Candida colonization,all the cultivated fungi were resistance to the 5 kinds of tested drugs,most obviously to ketoconazole.Conclusions:The prevalence of oral Candida carrier amongst the examined clinical patients is characterized by high isolation rate,high incidence among older patients with cardiovascular and cerebrovascular diseases or respiratory tract infection,and the most prevalent pathogen was mainly Candida albicans.Besides,most of the isolated strains are resistant to conventional anti-fungal agents.