Clinical feature and drug resistance analysis of lower respiratory tract fungal infection

Objective To investigate the clinical feature and analyze the susceptibility of pathogens in inpatients with lower respiratory tract fungal infection, and provide evidence for clinical reasonable selection of antifungal drugs.Method The data of inpatients with lower respiratory tract fungal infection from Jan 2008 to Dec 2009 were analyzed retrospectively with statistical method.Result Among 374 cases of lower respiratory tract fungal infection,there were 253 cases of candida albicans(67.6%),74 cases of candida glabrata(19.8%),28 cases of candida tropicalis(7.5%),10 cases of candida kruseis(2.7%),3 cases of other candida species(0.8%),4 cases of mold fungus(1.1%) and 2 cases of ropicalis(0.5%).The result of drug sensitivity test showed that the fungi were sensitive to many antifungal agents.The sensitivity rates to amphotericin B,voriconazole and fluconazole were high,while the resistance rate to itraconazole was the highest(up to 12.2%).Conclusion Candida albicans are still the main pathogen in patients with lower respiratory tract fungal infection,followed by candida glabrata and candida tropicalis.The infection rate of the three albicans was 94.9%.The drug resistance to itraconazole are the highest among five common antifungal agents.The prognosis of patients with community-acquired infection is better than that of nosocomial infections.