Akkirala Venkat Narsaiah, J. Kranthi Kumar
Abstract
The T-type calcium channel blocker and anti-ischemic drug, 1-[bis-(4-fluoro phenyl)-methyl]-4-cinnamylpiperazine (1) has been carried out in four steps with an average of 70% yield. This route is very convenient and can be used for large scale preparation of Flunarizine with high yields and at low cost.
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The T-type calcium channel blocker and anti-ischemic drug, 1-[bis-(4-fluoro phenyl)-methyl]-4-cinnamylpiperazine (1) has been carried out in four steps with an average of 70% yield. This route is very convenient and can be used for large scale preparation of Flunarizine with high yields and at low cost.
Key concepts: Flunarizine, Calcium channel blocker, Calcium channel, Yield (engineering), Channel (broadcasting), Calcium, Drug, Chemistry