Akkirala Venkat Narsaiah, Jatish Kumar
Abstract
The synthesis of the antimigraine drug 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine has been carried out in very good yields. The five-step synthesis started from bis(4-fluorophenyl)methanone. This route can be applied for large-scale preparation of lomerizine.
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The synthesis of the antimigraine drug 1-[bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine has been carried out in very good yields. The five-step synthesis started from bis(4-fluorophenyl)methanone. This route can be applied for large-scale preparation of lomerizine.
Key concepts: Chemistry, Piperazine, Simple (philosophy), Combinatorial chemistry, Stereochemistry, Organic chemistry, Philosophy, Epistemology