2010•Asian Journal of Research in ChemistryRequires access

New Simple UV Spectrophotometric Method for Estimation of Almotriptan Malate in Bulk and Pharmaceutical Dosage Forms

A. Suneetha, B. Syama Sundar

Abstract

A new simple, sensitive, precise, accurate and economical UV spectrophotometric method of analysis for almotriptan malate both as a bulk drug and in tablet formulations was developed and validated. The method employed methanol as solvent and the drug shows maximum absorbance at 227 nm with molar absorptivity of 0.8532×105 L/mol.cm. The linear regression analysis data for the calibration plot showed good linear relationship with r2 = 0.9999 in the concentration range of 1–5 μg/ml. Results of analysis were validated statistically and by recovery studies

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Key concepts: Molar absorptivity, Absorbance, Dosage form, Chromatography, Calibration curve, Linear regression, Solvent, Spectrophotometry