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2010•Asian Journal of Research in ChemistryRequires access

UV Spectrophotometric Determination of Risperidone in Bulk and Its Formulation

S. Kathirvel, Devala Rao G, Satyanarayana Sv

Open publisher page 3 citations

Abstract

A simple, sensitive and economical UV spectrophotometric method has been developed for the determination of Risperidone in bulk and tablet dosage forms. Risperidone is an anti-psychotic drug, which shows maximum absorbance at 238nm in 0.1N HCl. Beer's law was obeyed in the concentration range of 5–30 μg/ml with correlation coefficient of 0.9999. The standard plot clearly showed a straight line passing through the origin. The results of analysis were validated statistically and by recovery studies and found to be satisfactory. The proposed method was extended to pharmaceutical formulations and there was no interference of additives and excipients.

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What this paper is about

A simple, sensitive and economical UV spectrophotometric method has been developed for the determination of Risperidone in bulk and tablet dosage forms. Risperidone is an anti-psychotic drug, which shows maximum absorbance at 238nm in 0.1N HCl. Beer's law was obeyed in the concentration range of 5–30 μg/ml with correlation coefficient of 0.9999. The standard plot clearly showed a straight line passing through the origin. The results of analysis were validated statistically and by recovery studies and found to be satisfactory. The proposed method was extended to pharmaceutical formulations and there was no interference of additives and excipients.

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Available abstract

A simple, sensitive and economical UV spectrophotometric method has been developed for the determination of Risperidone in bulk and tablet dosage forms. Risperidone is an anti-psychotic drug, which shows maximum absorbance at 238nm in 0.1N HCl. Beer's law was obeyed in the concentration range of 5–30 μg/ml with correlation coefficient of 0.9999. The standard plot clearly showed a straight line passing through the origin. The results of analysis were validated statistically and by recovery studies and found to be satisfactory. The proposed method was extended to pharmaceutical formulations and there was no interference of additives and excipients.

Key concepts: Absorbance, Risperidone, Correlation coefficient, Chromatography, Dosage form, Chemistry, Pharmaceutical formulation, Materials science

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