2011•Asian Journal of Research in ChemistryRequires access

New Simple and Economical Spectrophotometric Methods for Estimation of Ezetimibe in Bulk Drug and Pharmaceutical Dosage Forms

Ramakrishna Kommana

Abstract

Two accurate, precise, rapid and cost effective methods were developed for the estimation of Ezetimibe in bulk drug and tablet dosage form. Wavelengths selected for quantitation were 233 nm in Methanol and 243 nm in 0.5 M NaOH respectively. In method-I (methanol) linearity for detector response was observed in the concentration range of 2–40 μg/ml and in method-II (0.5 M sodium hydroxide) linearity for detector response was observed in the concentration range of 2–30 μg/ml. The results of the analysis have been validated statistically. The method has been successfully applied in the analysis of marketed formulations.

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Key concepts: Ezetimibe, Sodium hydroxide, Dosage form, Methanol, Chromatography, Linearity, Chemistry, Materials science