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2011•Asian Journal of Research in ChemistryRequires access

Spectrophotometric Method for Estimation of Efavirenz from Tablet Formulation

Suhas B. Gurav, Dev Prakash, Anant N. Deshpande, Sandeep D. Walsangikar

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Abstract

A simple, sensitive and accurate spectrophotometric method was developed in ultraviolet region for the estimation of Efavirenz (EFA) in pure drug, pharmaceutical formulation. Linear response obtained was in the concentration range of 5–40 μg/ml with correlation coefficient of 0.9993 in solvent. Excellent recovery proved that the method was sufficiently accurate. There is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated by recovery studies according to ICH Q2B guidelines.

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What this paper is about

A simple, sensitive and accurate spectrophotometric method was developed in ultraviolet region for the estimation of Efavirenz (EFA) in pure drug, pharmaceutical formulation. Linear response obtained was in the concentration range of 5–40 μg/ml with correlation coefficient of 0.9993 in solvent. Excellent recovery proved that the method was sufficiently accurate. There is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated by recovery studies according to ICH Q2B guidelines.

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Available abstract

A simple, sensitive and accurate spectrophotometric method was developed in ultraviolet region for the estimation of Efavirenz (EFA) in pure drug, pharmaceutical formulation. Linear response obtained was in the concentration range of 5–40 μg/ml with correlation coefficient of 0.9993 in solvent. Excellent recovery proved that the method was sufficiently accurate. There is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated by recovery studies according to ICH Q2B guidelines.

Key concepts: Diluent, Chromatography, Correlation coefficient, Efavirenz, Dosage form, Chemistry, Mathematics, Medicine

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