Original Contribution MEASUREMENT OF C- REACTIVE PROTEIN BY TWO CLINICAL CHEMISRTY ANALYZERS

Clinical laboratory of the University Hospital, Pleven has the capacity to perform C-reactive protein (CRP) assay with high sensitivity tests by two biochemical analyzers closed type: Pentra 400 (Horiba ABX) and Cobas Integra 400 (Roche). This study is fulfilled to compare CRP- results obtained from the both analyzers with respect to investigate the possibility for interchangeability of these instruments. Both analyzers are based on the same method for determination of C-reactive protein - latex immunoturbidimetric. The analytical variation at different intervals of the referent range and outside is assayed. High correlation ( r > 0.9) between CRP values, obtained from the both analyzers has been shown for all investigated groups. However, a statistical significant difference in the mean values was established between the results from both instruments for some concentration groups. Analysis of the results obtained demonstrates that when CRP was used as a prognostic parameter despite, the high correlation between the results obtained from both analyzers, repeated measurements of CRP of a definite patient had to be made by one and the same analyzer.