UV-Spectrophotometric Determination for Simultaneous Estimation of Amlodipine Besylate and Telmisartan in Combination

Two simple spectrophotometric methods have been developed for simultaneous determination of Amlodipine besylate and Telmisartan in tablet formulation. Method 1 is Absorbance correction method, which is based on determination of Amlodipine besylate at 362 nm using its absorptivity value and Telmisartan at 292 nm. Method 2 is based on Absorbance ratio in which wavelengths selected were 326 nm, an isoabsorptive point and 292 nm as λmax of Telmisartan. Linearity was observed in the concentration range of 0.5-20, 0.5-15.5 µg/ml for AMLB and 3-24, 3-24 µg/ml for TELM by method A and B respectively. The methods can be routinely adopted for quality control of these drugs in tablet. Recovery study was performed to confirm the accuracy of the methods. The methods were validated as per ICH guidelines.