Stability Indicating Spectrophotometric Method of Amlodipine and Telmisartan in Bulk and Pharmaceutical Dosage Form

Two simple, rapid, precise and accurate spectrophotometric methods have been developed for determination of Amlodipine Besylate and Telmisartan by simultaneous equation method and stability study method in combined dosage form. The simultaneous equation method is based on measurement of absorbance at 242 nm and 231 nm as two wavelengths selected for quantification of Amlodipine and Telmisartan. Both methods obeyed Beer’s law in the concentration range of 5-30 µg/ml for Amlodipine and 2-7 µg/ml for Telmisartan. Amlodipine and Telmisartan were subjected to stress degradation under different conditions recommended by ICH. The samples so generated were used for degradation studies using the developed method. The proposed methods were validated and can be used for analysis of combined dosage tablet formulation containing Amlodipine and Telmisartan.