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2011•Unpublished venueRequires access

Determination of Tamsulosin in bulk and pharmaceutical dosage forms by UV spectrophotometric method

Manish Kumar Thimmaraju, V. V. R. Narasimha Rao

Open publisher page 2 citations

Abstract

A Simple, rapid, accurate and economical UV Spectro photometric method is developed for determination of tamsulosin in bulk and pharmaceuti cal dosage forms. In methanol, the λmax of the drug was found to be 224 nm. Using UV instrumen t (analytical), in this proposed method tamsulosin follows linearity in the concentration r ange 1 ‐ 5µg/ml with a correlation coefficient of 0.9989. Assay results were in good agreement wit h label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.23516 with excellent precision and accuracy.

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What this paper is about

A Simple, rapid, accurate and economical UV Spectro photometric method is developed for determination of tamsulosin in bulk and pharmaceuti cal dosage forms. In methanol, the λmax of the drug was found to be 224 nm. Using UV instrumen t (analytical), in this proposed method tamsulosin follows linearity in the concentration r ange 1 ‐ 5µg/ml with a correlation coefficient of 0.9989. Assay results were in good agreement wit h label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.23516 with excellent precision and accuracy.

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Available abstract

A Simple, rapid, accurate and economical UV Spectro photometric method is developed for determination of tamsulosin in bulk and pharmaceuti cal dosage forms. In methanol, the λmax of the drug was found to be 224 nm. Using UV instrumen t (analytical), in this proposed method tamsulosin follows linearity in the concentration r ange 1 ‐ 5µg/ml with a correlation coefficient of 0.9989. Assay results were in good agreement wit h label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.23516 with excellent precision and accuracy.

Key concepts: Tamsulosin, Relative standard deviation, Correlation coefficient, Dosage form, Standard deviation, Chromatography, Methanol, Linearity

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