ScholarLens Back to search
2011•Unpublished venueRequires access

UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF FINASTERIDE AND TAMSULOSIN IN COMBINED DOSAGE FORM

Manish Kumar Thimmaraju, V. V. R. Narasimha Rao, Srikanth Gurrala, Gangadi Jayapal Reddy

Open publisher page 8 citations

Abstract

A specific, rapid and simple UV spectrophotometric method with good sensitivity was developed and validated for the simultaneous determination of finasteride and tamsulosin in standard solutions and tablets. In methanol, the λmax of finasteride and tamsulosin was found to be 219 and 224nm respectively. Using an Elico UV – Visible spectrophotometer (model SL – 159) with matched quartz cells, in this proposed method both these drugs obeyed linearity individually and in mixture with the concentration range of 12.5-62.5 µg/ml for finasteride and 1-5 µg/ml for tamsulosin with a correlation coefficient of 0.9981 and 0.9989. Assay results were in good agreement with label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.5974 and0.4096 with excellent precision and accuracy.

About this research paper

What this paper is about

A specific, rapid and simple UV spectrophotometric method with good sensitivity was developed and validated for the simultaneous determination of finasteride and tamsulosin in standard solutions and tablets. In methanol, the λmax of finasteride and tamsulosin was found to be 219 and 224nm respectively. Using an Elico UV – Visible spectrophotometer (model SL – 159) with matched quartz cells, in this proposed method both these drugs obeyed linearity individually and in mixture with the concentration range of 12.5-62.5 µg/ml for finasteride and 1-5 µg/ml for tamsulosin with a correlation coefficient of 0.9981 and 0.9989. Assay results were in good agreement with label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.5974 and0.4096 with excellent precision and accuracy.

Why it matters

OpenAlex reports 8 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

A specific, rapid and simple UV spectrophotometric method with good sensitivity was developed and validated for the simultaneous determination of finasteride and tamsulosin in standard solutions and tablets. In methanol, the λmax of finasteride and tamsulosin was found to be 219 and 224nm respectively. Using an Elico UV – Visible spectrophotometer (model SL – 159) with matched quartz cells, in this proposed method both these drugs obeyed linearity individually and in mixture with the concentration range of 12.5-62.5 µg/ml for finasteride and 1-5 µg/ml for tamsulosin with a correlation coefficient of 0.9981 and 0.9989. Assay results were in good agreement with label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.5974 and0.4096 with excellent precision and accuracy.

Key concepts: Finasteride, Tamsulosin, Chromatography, Relative standard deviation, Dosage form, Chemistry, Correlation coefficient, Methanol

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF FINASTERIDE AND TAMSULOSIN IN COMBINED DOSAGE FORM — Research Paper | ScholarLens