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UV SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF FINASTERIDE IN BULK AND PHARMACEUTICAL DOSAGE FORM

Manish Kumar Thimmaraju, V. V. R. Narasimha Rao, Srikanth Gurrala, Gangadi Jayapal Reddy

Open publisher page 4 citations

Abstract

A Simple, rapid, accurate and economical UV Spectrophotometric method is developed for determination of finasteride in bulk and tablets. In chloroform, the λmax of the drug was found to be 245 nm. Using UV instrument (analytical), in this proposed method finasteride follows linearity in the concentration range 10 – 120 µg/ml with a correlation coefficient of 0.9993. Assay results were in good agreement with label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.2319 with excellent precision and accuracy.

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What this paper is about

A Simple, rapid, accurate and economical UV Spectrophotometric method is developed for determination of finasteride in bulk and tablets. In chloroform, the λmax of the drug was found to be 245 nm. Using UV instrument (analytical), in this proposed method finasteride follows linearity in the concentration range 10 – 120 µg/ml with a correlation coefficient of 0.9993. Assay results were in good agreement with label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.2319 with excellent precision and accuracy.

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Available abstract

A Simple, rapid, accurate and economical UV Spectrophotometric method is developed for determination of finasteride in bulk and tablets. In chloroform, the λmax of the drug was found to be 245 nm. Using UV instrument (analytical), in this proposed method finasteride follows linearity in the concentration range 10 – 120 µg/ml with a correlation coefficient of 0.9993. Assay results were in good agreement with label claim. The methods were validated statistically and by recovery studies. The relative standard deviation was found to be 0.2319 with excellent precision and accuracy.

Key concepts: Finasteride, Dosage form, Relative standard deviation, Chloroform, Chromatography, Correlation coefficient, Linearity, Accuracy and precision

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