Comparison Evaluation of Effect of three Different Blood Glucose Lowering Drugs in Streptozotocin Induced Diabetic Rats

Diabetes mellitus (DM) is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. The objective of present study was to compare the effect of three different blood glucose lowering drugs in streptozotocin induced diabetic rats. In this study, 20 male Wistar rats (220–250 g and 2-3 month age) were selected then were divided into four equal groups: group1; healthy control rats received standard diet; Group 2 diabetic rats received standard diet plus acarbose at a dose of 25mg/kg daily through gastric gavage for 8 weeks; Group 3, diabetic rats received standard diet plus pioglitazone at a dose of 1mg/kg daily through gastric gavage for 8 weeks; Group 4, diabetic rats received standard diet plus repaglinide at a dose of 10mg/kg daily through gastric gavage for 8 weeks. Diabetes was induced by intraperitoneal injection of streptozotocin at a dose of 60 mg/kg body weight. After 48 h, animals with fasting blood glucose levels greater than 250 mg/dl were considered diabetic and then included in this study. Our data showed that anti-diabetic drugs have good hypoglycemic effects by improvement of pancreatic cells and islets.