2010•International Journal of Pharma and Bio SciencesRequires access
ANTI-DIABETIC EFFECT OF ETHANOLIC AND METHANOLIC LEAVES EXTRACT OF CENTELLA ASIATICA ON ALLOXAN INDUCED DIABETIC RATS
Priyanka Chauhan, Ishdutt Pandey, Vinod Kumar, Vijay J Singh
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Abstract
The Ethanolic and Methanolic extracts of the leaves of Centella asiatica (Family- Umbelliferare) were tested for anti-diabetic activity, by glucose toler ance test in normal rats and alloxan induced diabet ic rats. Ethanolic and methanolic extracts had shown signifi cant protection and lowered the blood glucose level s to normal in glucose tolerance test. In alloxan induce d diabetic rats the maximum reduction in blood gluc ose was observed after 3h at a dose level of 250 mg/kg of body weight. The percentage protections by ethanolic and methanolic extracts were 48% and 30% respectively. In long term treatment of alloxan induced diabetic rats, the degree of protection was determined by measuring blood glucose, triglycerid es, cholesterol and urea levels on 0,3,5,7 and 10th day . Both the extracts showed a significant anti- diab etic activity comparable with that of glibenclamide. The histopathological studies during the long-term treatment have shown to ameliorate the biochemical damages caused by alloxan. These results indicate t hat the Centella asiatica leaves possess significant anti ‐ diabetic activit y.