2009•Research Journal of Pharmacognosy and PhytochemistryRequires access
Antidiabetic Activity of Marsilea quadrifolia linn in Alloxan-Diabetic Rats
Shirish Dongare, A. P. Maske, Shivanand M. Patil, R. P. Umbare, Gitanjali Mate
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Abstract
The different extracts of the Marsilea quadrifolia linn (Family-Marsileaceae) were tested for anti-diabetic activity, by normal rats and alloxan induced diabetic rats. Aqueous and methanol extracts had shown significant protection and lowered the blood glucose level. In alloxan induced diabetic rats the maximum reduction in blood glucose was observed after 72h at a dose level of 200mg/kg body weight. In short term treatment of alloxan induced diabetic rats was determined by measuring blood glucose levels on 0,24,48 and 72h. Both the extracts showed a significant anti-diabetic activity comparable with that of glibenclamide. These results indicate that the Marsilea quadrifolia linn plant possess significant anti–diabetic activity.