ANTIDIABETIC ACTIVITY ON METHANOLIC EXTRACTS OF SCHREBERA SWIETENOIDES ROXB. ROOTS IN STREPTOZOTOCIN INDUCED DIABETIC RATS

Objective: The aim of study was to evaluate acute toxicity and antidiabetic activity of methanolic extract of Schrebera swietenoides roots in streptozotocin induced diabetic rats. Methods: Acute toxicity of the methanolic extracts of Schrebera swietenoides roots was studied in Wistar albino rats at a dose level upto 2 g/kg b.w. The animals were also closely examined for signs of intoxication, lethargy, behavioral modification and morbidity. The plant was evaluated for antidiabetic activity against Streptozotocininduced diabetic model in different concentrations of 100,200 and 400 mg/kg body weight. The mean and percent blood glucose reduction levels were calculated and comparable with the standard drug, glibenclamide (0.45 mg/kg b. w). Results: The extracts did not produce any toxic signs during the observation period for 24 h. The oral administration of 400 mg/kg b. w of methanolic extract of Schrebera swietenoides roots showed significant (P<0.05) decrease in blood glucose levels up to 18 th h, more significant (P<0.01) decrease in blood glucose levels at 4 th and 12 th h and highly significant (P<0.001) decrease in blood glucose levels at 8 th h respectively. Conclusions: From the studies it is concluded that, the methanolic extract of Schrebera swietenoides roots is suitable to prepare ayurvedic formulations for the treatment of diabetes.