COMPARATIVE QUANTITATIVE DETERMINATION OF PARACETAMOL BY RP-HPLC AND UV- SPECTROPHOTOMETRY FROM ITS FORMULATED TABLETS

These both methods have been described for the quantitatively determination of paracetamol from the single formulated drug tablets by reverse phase high performance liquid chromatography (RP-HPLC) and UV-Spectrophotometry techniques. These both methods were reported in terms of linearity, accuracy, precision and limit of detection and limit of quantification. In both methods the linearity were computed from regression analysis. These both methods showed good linearity over the concentration range of 5–50 µg/mL. The linearity was obtained for paracetamol by reverse phase high performance liquid chromatography (RP-HPLC) R2=0.995 and by UV-Spectrophotometry R2=0.988. The accuracy was checked by recovery method. The recovery coefficient variation (CV %) was obtained 2.90 for RP-HPLC and 0.87 for UV-Spectrophotometry. In both cases coefficient variation was less than 10; therefore proposed methods were successfully applied for the analysis of in its commercial tablets. Any one of the validated method can be used for the analysis of formulated paracetamol tablets.