Delay of wound healing in stressed Balb/c mice

Background: Stress gradually makes immune system weak and suppresses it, therefore makes body susceptible to various types of diseases, and may delay the healing of the wound. The aim of this study was to show the effects of cold and immobilization stresses on wound healing in Balb/c mice. Materials and Methods: In an interventional study 30 female Balb/c mice were divided into 3 groups randomly. First and second groups were exposed to cold and immobilization stresses respectively and third group (control group) left with no stress. Wound healing was checked every other day and compared with each other. Results: Results showed that the mean of wound sizes of stressed groups was bigger than control group (p<0.05).The wounds healing duration was 11 days in control group and 15 days in test groups. Conclusions:Stress has negative effect on wound healing, therefore a peaceful and calm environment is recommended for patients with serious injuries.