2001•Journal of Antimicrobial ChemotherapyRequires access

Treatment of Absidia corymbifera infection in mice with amphotericin B and itraconazole

Juan Alejandro Neira Mosquera

Abstract

The activities of amphotericin B and itraconazole were studied in a temporarily neutropenic murine model of disseminated Absidia corymbifera infection, caused by two different strains. Amphotericin B MICs were 0.25 mg/L for both strains and itraconazole MICs were 1 and 2 mg/L. Amphotericin B was effective in vivo with both isolates. Itraconazole was less effective.

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Key concepts: Itraconazole, Amphotericin B, Microbiology, In vivo, Mycosis, Medicine, Biology, Antifungal