Clinical Analysis of 237 Cases of Invasive Fungal Infection

Objective To evaluate the efficacy and safety of fluconazol, itraconazol and amphotericin B in the treatment of invasive fungal infection. Methods 237 patients with invasive fungal infection were treated with routine dose of fluconazol(107 cases), itraconazole(84 cases) and amphotericin B(46 cases). 65 cases, showed no improvement on fluconazol treatment, were changed to use itraconazole or amphotericin B, and 39 cases, showed no improvement on itraconazole treatment, were changed to use amphotericin B or amphotericin B lipid. Results Total cure rate and effective rate were 54.85% and 72.57%, respectively. The effective rate of the patients used fluconazol was 39.25%, lower than those used itraconazole or amphotericin B, 53.57% and 56.52%, respectively. The effective rate of the patients changed from fluconazol to itraconazole or amphotericin B were 76.93% and 84.61%,respectively. Conclusion The anti-fungal spectrum of itraconazole and amphotericin B are broad. The effective rates of itraconazole and amphotericin B are similar, higher than that of fluconazol. Fluconazol and itraconazol are safe, but amphotericin B has stronger side effect.